– ???? ??????? ??????? ??? ??????? ????????? ????? ??? ?? ??????: ???? ??????? ??????? ??????? ?? ?????? ?????? ?????? ?????? ?? ??????

– ?????? ????? ???? ?? ????? ?????? ????? ????? ?????? ?? ???? ?????? ??????? ????? (OA) ?? Kellgren and Lawrence ?(K-L) ?? ?????? ???????

– ???? ????? ??????? ??????? ??????? ???????? ???? 16 ????? ?????? ????? ????? ??? ?? ??? ????????? ?????? ???????? ?? ?????????

– ???? ????? ????? ???? ?? ????? ????? – ???? ????? ??? ?? ????? ?????? ???????? ?? ???? ????? ?????? (OA)

Chairman of Nature Cell and Lead Researcher of JointStem Development, Dr. Jeong-Chan Ra (nature Cell)

????? ????? ? ????? ????? ??? ( Nature Cell) ??? ( 17 ???? 2021) ?? ??????? ??????? ?? ??????? ???????? ??????? ???????? JointStem ? ????? ??? ???? ??????? ??????? ?? ?????? ?????? ?????? ??????? ?? ?????? ???????? ??????? ??????? ??????? ?? ??????? ??????? (AdMSC)? ?? ?????. ?? ????? JointStem ?????? RBio? ???? ??????? ??????? ??????? ??? ( Nature Cell).

???? ????? ??? ( Nature Cell) ????? ??????? ???????? (CSR) ?? 14 ???? 2021 ?? LSK Global PS? ??? ????? ??????? ????????? (CRO)? ??? ??? ????? ??????? CSR ?? ?????? ?????? JointStem ?????? ????? ?????? ????? ????? ?????? ?? ?????? ????? ?????? ?? ??? ?????? ????? ?????? ????? ?? ?????? 3 KL ???? ?? ????? ???????.

?? ????? JointStem ??? ??? 2005 ??????? ????? ????? ?????. ?????? ???  ????? ???????? ?? ????????? ?? ??? ???????. ????? ?? JointStem ????? ???? ????? ????? ?????? ??????? ????? ????? ???? ??? ?? ?????? ????? ?? ???????? ??????? ?????? ???? ????? ?????.

????? ?? CSR ? WOMAC (???? ????? ??????) ? VAS (???? ?????)? ????? ??????? ??????? ??????? ??????? ???????? ?? ????? ?? ?????? ??? ????? ??? ????? ???? ??? 24 ??????? ?? ?????? ?? ??? ????? ?????? ???? ???? ?????? ???????? ????????? ????? ????? ??? ????? ??????? ? ??? ????? ??????? ????? ??????? ??? ????? ??????? ?? ?????? ??????? ????? ??? ?????? ?????? ??? JointStem ??????? ??? ?????? ?????? (p = 0.0002 ? p <0.0001 ??? ????? ?????).

???? ???? ????? ?????? ?? ??????? ???????? ??? ???? ???? p ??? ?? 0.05? ??? ???? ???? ????? ????? ?? ????? ????? ??????? ??? ???? ???? p ???? ?? 0.05. ??? ????? ?? ??????? ??????? ????? ??? ????? ?? ?????? ????????.

??????? ??????? ???????? ?????? ?? ???????? ??????? WOMAC (?????? ???????? ?????? ????? ??????? ?????? ???????)? ?????? KOOS (????? ????? ?????? ?????? ??????) ? SF-36 (????? ???? ??????)? ??????? ???????? ???????? ??????? ??????????? ??? ?? ????? ???? ???? ???? ??????? ???? ????? ??????.

??? ?????? ???? ????? ??????? ???????? ??????? WOMAC (????? ??????? ?????? ???? ?????? ???????) ??? ??????? ?????? ??? ??????? ?????????. ?? ????? ????? ?? ?????? ???? JointStem ????? ?????? ????? ???????? ????????? ?? ?????? ????? ?????? ???????? (?? ???? p = 0.0043? 0.0307? 0.0018). ?? ????? KOOS (????? ?????? ????? ????? ????? ??????) ?? ???? ????? ???????? ??????? ??? ??????? ?????? ???????? ?? ?????? ??????? ???????? ????????? ????? ??????? ?? ???? ????? ???????? ??????? ?????? ??????? ????? ????????. ????? ?????? ?????? ???? JointStem ?????? ?? ????? ??????? ?? ???? ????? ???????? ??????? (?? ???? p = 0.0002? 0.0002? 0.0017? 0.0003? 0.0060).

??????? ?? SF-36? ???? ????? ???? ??????? ???? ????? ????? ??????? ?????? ????? ??????? ???? ????? ?? ?????? ??? JointStem? ?????? ?????? ?????? ????? ??????? ??? ????? ??????? (?? ???? p = 0.0084? 0.0038). ??? ???? ???? IKDC? ???? ???? ????? ?????? ?????? ??????? ???? ???? ?? ?????? ??? JointStem? ?????? ?????? ?????? ?????? ????? ?? ??????? ????????? (p <0.0001).

?? ????? ?????? ???????? ???? ????? ???? ?? ?????? ??? JointStem ?? ?????? 3 ??? 2 (??????) ?? ?? K-L ?? ?????? 4 ??? 3 (???? ????)? ??? 104 ?????? ?? ??? ?????? ??? ??? ??? ??? ??? ??????. ??? ???? ?? ????? ?? ???? ?? ?????? ??? ?????? ?????? ????????.

???? ????? ??????? ??????? ?????????? ?? ??? ????? ??????? ????? ?????? ?? ??? ?????? ??????? ???? ??? ????? ??????? ???? ??? ??? ???? ????? ???? ??? ??????? ???? ????? ??? ??????? ???? ??????? ?? ?? ??????? ?? ?????? ????? ?? ??? ???????? ???????? ???? ???? ??????? ????? ???? ?? ?????? ??? JointStem ?????? ??????? ?????? ??????.

 ?? ??????? ??? ?? ??? ?????? ???? ????? ???? ?????? ??? ???? ????? ??????? ??????? ????????? ?????? ???? ??? ?? ?????? ??? JointStem ?? ??? ???????? ?? ?????? ??? ?????? ?????? ????????. ?????? ???????? ??? ?????????? ??? ???? ?? ??????? (?? ???? p = 0.0338? 0.0008)? ???? ???? ??????? ?? ??? JointStem ??? ?? ??? ?????? ???? ????? ???? ?????? ???? ????? ?????? ??????? ?????? ??????.

??????? ?????? ???????? ?? ??? ???? ?? ??? ??? ???? ????? ?? JointStem. ???????? ??? ???? ?? ??? ?????? ??? ????? ????? ?? ?????? ??? JointStem ????????? ?? ?????? ??? ?????? ?????? ??????. ??? ?? ???? ??????? ???????? ?? JointStem ?? ??? 2008? ?? ??? ???? ???? ????? ?????? ?????? JointStem.

???????? ??? ???? ???? ????? ??????? ??????? ?????????? ?????? ??? ????? ?????? ??????? ???????? ??????? ??????? ?? JointStem   ??? ?? ???? ??????? ??? ??? ????? ?? ???? ????? ???? ?? ??? ??? ????? ??? ????? ?????? ???? ?????? ?? ??????.

??????? ????? ???? ?? ?? ????? ???????? ??????? ???? ??? ????? ????? ???????? ?????????

??? ???? ???? ??????? ??????? ??????? ?? ????? JointStem? ??????? ????? ???? ??? “????? ??? ?? ?????? ?? ???? ??????? ??????? ?? ????? JointStem ????????. ????? ?? ??? ?? ????? ??????? ??????? ???????. ???? ????? ???? ????? ?? ??? ???? ????.

????? ?. ??: “??? ???? ????? ?????? ?????? ?????? ??????? ??????? ??????? ??? ??????? ???? ?????? ??? ?????? ????? ??? ???????. ????? ?????? ?????? ??? ?????? ??? ???????? ??? JointStem ????? ???? ?? ???? ?????? ??????? ???????. “

?????:

?? ?? ????? ???? JointStem?

????? ???? JointStem ?? ??? ???? ??????? ??????? ?? ?????? ?????? ????? ?????? ?? ????? ?????? ??????? ?? ?????? ????? ?????? ??????? ??????? ??????? ?? ??????? ??????? (AdMSC) ???? ???? ??? ????? ????? ???? ?????? ?????? ?????. ????? ??? ???? ???? ???? ????? ????? ??????. ??? ??? ??????? ?????? ???????? ???????? ????? ?????? ??????? ???????? ?? ????? JointStem ????? ??????? ???? ????? ????? ????? ???? ????? ??? ????? ?????. ??? ???? ????? ???? ?????. ????? ?????? ??? ?? ???? ??? ??? ???? ????? ???? ?????? ???? ???? ??????? ?????? ????????? ?? ???????. ??? ???? ?? ???? JointStem ????? ????? ?????? ?? ?????? ???? ?? ??????? ?? ???? JointStem ?????? ?????? ?? ????? ???? ?????? ??????.

Dr. Jeong-Chan Ra

????? ??????? ????????

??? ?????  JointStem ??? ??? 2005? ??? ????? ?????? ??????? ???????? 1 ? 2 (??? ???????? ?????? ?? ??? 2008) ???????? 2 ? (??? ???????? ????? ?? ??? 2014) ???????? 3.

??? ???????? ??? ??????? ??????? ?? ??????? ?? ????? 2019 ??? ?????? ???? ??????? ??????? ???????? ??????? ?????? ?????? ??????? ???????. ????? ???? ?????????? ??? 13 ??? ?? ??? ?????? ????? ????? ?? ?? ???????? ??? ?????? 252 ?????? ?? ??????? 3 ?? ??????? ????????. ?? ???????? ???????? ??? ???????? ??? JointStem ??????? 2 ?? ??? ????? ?????? ??????? ??? ??????? ?????. ??? ???? ????? ?????? ??????? 2 ? / 3 ? ?? ??????? ????????.

?? ????? ????? ?????? ?????? JointStem 3 ????? ??????? ??????? ?? Kellgren-Lawrence (KL) ?? ?????? 3. ???? ????? ??????? ?? ??????? ???????? ?? ????? ????? ??????? ??? ??? ?????? ?????? ????? ?????? ?? ????? ?????? ?????? ????? ????? ??????? ??????? ?????? ?????? JointStem? ?? ??????? WOMAC (???? ????? ??????) ? VAS (???? ?????) ???????? ??????? ???????. ??? ????? ??????? ?? ??? ??????? ???????? ??????? ?????? ??? ????? ?????? ??? ????? ??????? ??? ?? ?????? ??????? ??????. ??? ???? ??? placebocomparator ????? ?? ???? ?? ??? ???? ???? ?????? ???? ????? ???? ?? JointStem ???????? ??????? ??????? ??????? ?? ?????? ?????? ??????.

?? ????? ??? ???? ?? 13 ????? 2019? ??? ??? 334 ??????? ??? ????? 261 ?????? ???? ??????. ?? ??? JointStem ?? ???? placebocomparator ?? 252 ?????? ?? ??? 261 ??????? ??? ????? 252 ?????? ?? ????? ??????? ???????? ??? ??????? ????????.

????????? ???? ??????? ??:

Dr. Sung Keun Kang, Vice President of Biostar Stem Cell Research Institute (02-6978-9601)/Jae Uk Shim, Vice President (02-6978-9268)